Wharton's Jelly materials
A focused material category selected against source documentation, handling requirements and continuity of access.
Category details open inside a Trade Account
Biologics · Verified trade supply
Precision begins
before delivery.
VURV One™ selects biologic materials on documentation, handling fit and logistics reliability. Every lot stays connected to its records from source through receipt for verified Trade Accounts.
Per lot
Documentation connected to the exact material received
Defined
Temperature requirements established before movement
Prepared
Receiving and storage readiness confirmed before a first order
Traceable
Shipment records linked from source through delivery
The Martin Triangle™
The framework the products were designed around.
Effective healing follows a three phase sequence: 1. Control inflammation · 2. Rebuild structure · 3. Restore function
Inflammation
Healing begins with systemic inflammation reduction followed by focal inflammatory control. Umbilical cord derived MSC exosomes support this process by promoting M2 macrophage polarization and reducing inflammatory signaling.
The Martin Triangle™ was developed by Scott M. Martin, M.D., M.S., founder of the Institute of Regenerative Education.
- Zhao J et al. MSC exosomes and M2 macrophage polarization.
- Teo KYW et al. Exosomes mediate anti inflammatory M2 phenotype.
- Arabpour M et al. Exosome mediated inflammatory phenotype regulation.
- Wang J et al. MSC EVs alter macrophage polarization across disease states.
- Watanabe Y et al. EV induced M2 polarization (Scientific Reports).
- Jadalannagari S et al. Decellularized Wharton's Jelly as a 3D scaffold.
- Gupta A et al. Safety and efficacy of Wharton's Jelly for knee OA.
- Lai A et al. Wharton's Jelly outcomes in rotator cuff applications.
- Isa IL Mohd et al. Wharton's Jelly hydrogel with collagen II and hyaluronic acid.
- Troyer DL & Weiss ML. Primitive stem cell population in Wharton's Jelly.
Wharton's Jelly
A collagen based extracellular matrix.
Derived from the connective tissue of the umbilical cord, Wharton's Jelly is a collagen based extracellular matrix that supports healing and cell regrowth in areas of damaged or deteriorated tissue.
Proteoglycans
Macromolecules that play a major role in the makeup of the fibrous connective tissue that provides structural support.
Growth Factors
Stimulate tissue and cell regrowth.
Hyaluronic Acid
Helps cushion and hydrate restored tissue.
Cytokines
Direct blood flow through cell walls, promoting healing.
Collagens Type I & III
Provide tissue elasticity, strength and support, and promote healing.
What each option contains
| Option | Proteoglycans | Hyaluronic Acid | Growth Factors | Cytokines | Collagen I & III |
|---|---|---|---|---|---|
| Steroids | Does not contain Proteoglycans | Does not contain Hyaluronic Acid | Does not contain Growth Factors | Does not contain Cytokines | Does not contain Collagen I & III |
| Hyaluronic Acid | Does not contain Proteoglycans | Contains Hyaluronic Acid | Does not contain Growth Factors | Does not contain Cytokines | Does not contain Collagen I & III |
| PRP | Does not contain Proteoglycans | Does not contain Hyaluronic Acid | Contains Growth Factors | Contains Cytokines | Does not contain Collagen I & III |
| Wharton's Jelly | Contains Proteoglycans | Contains Hyaluronic Acid | Contains Growth Factors | Contains Cytokines | Contains Collagen I & III |
Patients affected by
- Neuropraxic disorders
- Musculoskeletal conditions
- Soft tissue conditions
- Cartilage defects
General health & aesthetics
- Hair loss
- Skin conditions
- Age lines
- Beauty & wellness
Routes of administration
- IV infusion
- Microneedling
- Subcutaneous injection
Specialties using it
- Pain Management
- Orthopedics
- Cosmetic Surgery
- Podiatry
- Dermatology
- Medically Integrated Practices
Biologic categories
A focused line, by design.
The public page names broad categories only. Specific formats, documentation and availability open inside a verified Trade Account.
Exosome materials
Documented material formats evaluated lot by lot, with temperature and receiving requirements made clear before ordering.
Formats and availability open inside a Trade Account
Documentation discipline
Every handoff has a record.
Source records, lot documentation and handling requirements are reviewed as one chain. The standard follows the material, not the name on the box.
01
Source qualification
Material is evaluated against written specifications, process controls and the records a source can produce before it is considered for the line.
02
Lot documentation
Each lot is tied to its own documentation. A certificate of analysis for the exact material received is available upon request.
03
Handling plan
Temperature, packaging and transit requirements are set for the material before logistics are arranged.
04
Shipment traceability
The delivery remains linked to its source and lot records so questions can be resolved against the exact shipment.
Logistics and handling
Ready at both ends.
Receiving windows
Delivery timing is aligned with the hours and people available to receive temperature-sensitive material.
Storage readiness
Required storage conditions and capacity are reviewed before a first order is arranged.
Excursion response
Any temperature exception is assessed against the shipment record and the material's documented handling window.
Restock cadence
Reorders can be planned around actual usage so timing and storage capacity stay aligned.
Studies
The literature, on hand.
Main BJ, Valk JA, Maffulli N, Rodriguez HC, Gupta M, Stone IW, El Amin SF III, Gupta A.
Journal of Orthopaedic Surgery and Research (2020) 15:527. PROSPERO CRD42020182487.
A registered PRISMA protocol for systematically reviewing Wharton's Jelly across orthopedic regenerative applications. Notes that Wharton's Jelly is largely composed of mesenchymal stem cells and extracellular matrix components including collagen, chondroitin sulfate, hyaluronic acid and sulfated proteoglycans.
Gupta A, Maffulli N, Jain VK.
Biomedicines (2023) 11:2425.
Red blood cells in PRP preparations release free hemoglobin, iron and hemin when damaged, activating inflammatory pathways and oxidative stress that can contribute to chondrocyte apoptosis and degenerative joint damage.
Radiological Society of North America.
November 29, 2022.
Two studies from the Osteoarthritis Initiative cohort found corticosteroid knee injections were significantly associated with osteoarthritis progression, in the lateral meniscus, lateral cartilage and medial cartilage, while hyaluronic acid injections were not.
Education & training
The framework, taught in full.
Institute of Regenerative Education (IORE). A professional learning hub dedicated to advancing the safe, ethical and evidence based practice of regenerative medicine. Founded by Scott M. Martin, M.D., M.S., the same framework is taught in full: protocols, case selection and clinical application.
Evidence based treatment protocols curated by experienced practitioners
Structured coursework and hands on protocol training
One on one mentorship with experienced practitioners
Registry and certification
For physicians and surgeons, researchers and scientists, clinic owners and practitioners, and allied healthcare professionals.
IRB Registry
Become a Certified Investigator.
The IORE Registry is an observational registry following patients who have received biologics, a safety and efficacy database spanning the full spectrum of regenerative care.
Participating providers track outcomes on every patient they treat, compare those outcomes against other procedures they have performed, and contribute that data to the registry. It gives the physician a documented record of their own clinical results, and it builds the evidence base the field has been missing.
The registry supports structured safety monitoring protocols, outcomes focused protocols, retrospective and observational data review, and adverse event documentation for both autologous and allogenic products.
Getting started
Prepare the account.
Then open the line.
01
Apply
Tell us about the organization, legal entity, delivery address and people authorized to order.
02
Verification
We confirm the entity and the people authorized to use the Trade Account.
03
Handling review
Your team reviews receiving, temperature and record-keeping requirements before a first order.
04
Catalog access
Once approved, biologics availability, documentation and trade pricing open inside the account.
Availability, trade pricing and lot documentation are visible only inside an approved Trade Account.
Verified Trade Accounts
Biologics, handled deliberately.
Apply for a VURV One™ Trade Account to review the biologics line, documentation and handling requirements.